https://www.sciencedirect.com/science/article/pii/S14439506240004...

https://www.sciencedirect.com/science/article/pii/S144395062400043X

DMTN (dematin) activation can be cardioprotective because it plays a significant role in maintaining the structural integrity and function of cardiomyocytes (heart muscle cells). Here are a few ways in which DMTN activation contributes to cardioprotection:

1. Cytoskeletal Stability: Dematin helps link the actin cytoskeleton to the plasma membrane, contributing to the structural stability of cardiomyocytes. This structural integrity is crucial for the mechanical function of the heart, especially during the repeated cycles of contraction and relaxation.

2. Cell Signaling: By maintaining the organization of the cytoskeleton and its connections to the cell membrane, dematin can influence various signaling pathways that regulate cell survival, growth, and response to stress. Proper signaling is essential for cardiomyocyte function and adaptation to stress conditions such as ischemia (reduced blood flow).

3. Oxidative Stress Reduction: Activation of cytoskeletal proteins like dematin may help reduce oxidative stress within cardiomyocytes. Oxidative stress is a major contributor to cardiac damage during conditions like myocardial infarction (heart attack).

4. Ion Channel Regulation: The proper organization of the cytoskeleton facilitated by dematin can influence the localization and function of ion channels in the cardiomyocyte membrane. This regulation is vital for maintaining proper cardiac electrical activity and preventing arrhythmias.

5. Prevention of Apoptosis: Dematin activation can help in preventing apoptosis (programmed cell death) of cardiomyocytes by maintaining cytoskeletal integrity and cell signaling pathways that promote cell survival.

Overall, by supporting the structural and functional integrity of cardiomyocytes, DMTN activation can help protect the heart from various forms of stress and injury, contributing to overall cardiac health and resilience.