Yes the aim is to make the PD-1 inhibitors work better. While the population that would initially be trial is those patients that don’t respond to the checkpoint inhibitor drugs, if bisantrene worked on the non-responder patient population it would soon be given to all patients getting a PD-1 inhibitor.
The reason why is nobody really knows in advance if a patient will respond to a PD-1 inhibitor or not. You have the patient the best combination upfront, especially if the toxicity profile is low.
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